Landmark Trials

Sticares InterACT manages acute and chronic heart failure trials on both investigational drugs and devices. We also prepare, coordinate and carry out heart failure surveys.

Our multinational endeavors include:

SHIFT Systolic heart failure treatment with the If inhibitor ivabradine trial
SHAPE survey Study of heart failure awareness and perception in Europe
CANCION device study Study of the Cancion - Cardiac Recovery System (CRS) for the use of treatment of acute decompensated heart failure

 

Results of landmark trials are published in international peer-reviewed journals such as the European Heart Journal, The Lancet and Circulation.

Our landmark trials on coronary artery disease include:

EUROPA          European trial on reduction of cardiac events with perindopril in stable coronary artery disease
BEAUTIFUL    Morbidity-mortality evaluation of the If inhibitor ivabradine in patients with coronary disease and left ventricular dysfunction
SIGNIFY         Study assessing the morbi-mortality benefits of the If inhibitor ivabradine in patients with coronary artery disease

 

Our trials on myocardial infarction include:

PREAMI Perindopril and remodeling in elderly with acute myocardial infarction

 

Our trials on atherosclerosis include:

PERSPECTIVE

Perindopril’s prospective effect on coronary atherosclerosis by angiography and intravascular ultrasound evaluation

 

PERFECT

Perindopril-function of the endothelium in coronary artery disease trial: the PERFECT sub-study of EUROPA

Our trials on diabetes include:

PERSUADE

Perindopril substudy in coronary artery disease and diabetes: the Diabetic substudy of EUROPA

Our trials on hypertension include:

HYVET

Hypertension in the very elderly trial with perindopril / indapamide

 

Perindopril-005

Effect of once-a-day oral administration at bedtime of a delayed release formulation of perindopril on safety and blood pressure in hypertensive adult patients

 

ADDING & M-ADDING

Evaluation of the efficacy and tolerability of the fixed combination of manidipine and delapril in hypertensive patients non responsive to treatment with manidipine alone

 

PREMIUM

Study of the efficacy and safety of perindopril/amlodipine combinations, including a comparison with an irbesatan/hydrochlorothiazide combination in mild to moderate hypertension